Discriminating value of total minor physical anomaly score on the Waldrop physical anomaly scale between schizophrenia patients and normal control subjects.

نویسندگان

  • Stefan T Sivkov
  • Valentin H Akabaliev
چکیده

Minor physical anomalies (MPAs) are slight structural aberrations that are believed to be associated with abnormal neurodevelopment. Studies of schizophrenia patients show that these patients score higher in MPAs than normal controls. The present study attempted to assess the potential value of MPAs as a classifying test in the status schizophrenia patient versus normal control. Seventy-six schizophrenia patients and 82 normal controls were assessed for MPAs using the Waldrop Physical Anomaly Scale, and specificity, sensitivity, and predictive value of the total MPA score were determined. A significantly higher percentage of schizophrenia patients than normal controls had high numbers of MPAs. Total MPA scores higher than 4 showed the most balanced set of sensitivity (76.3%), specificity (72.0%), and positive (71.6%) and negative (76.6%) predictive values for schizophrenia and were the cutoff scores that optimally discriminate schizophrenia patients from normal controls. Schizophrenia patients showed a higher percentage of subjects with prominent MPA scores. The results are consistent with the hypothesis that MPAs might reflect extragenetic stressful events and present total MPA score as a reliable index in distinguishing between schizophrenia patients and normal controls.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

The incidence of minor physical anomalies in adult male schizophrenics.

The Waldrop anomaly score was used to assess the incidence of minor physical anomalies among 40 adult male Caucasian schizophrenics. This sample had a higher group mean anomaly score than that reported for the normal population (p less than .001). Those with higher anomaly scores evidenced poorer premorbid adjustment (p less than .05). A significant relationship also existed between anomaly sco...

متن کامل

اسکیزوفرنیا و شیوع ناهنجاری‌های مادرزادی خفیف

AbstractObjectives: The aim of this study was to compare the prevalence of minor physical anomalies in schizophrenic and physically ill patients. Method:This was a case-control study.50 patients with the diagnosis of schizophrenia were com- pared with 50 physically ill patients on the basis of the prevalence of congenital anomalies.Selected in a three month period, the first group was comprised...

متن کامل

No Association of Functional Polymorphisms in Methlylenetetrahydrofolate Reductase and the Risk and Minor Physical Anomalies of Schizophrenia in Korean Population

Methylenetetrahydrofolate reductase (MTHFR), a critical enzyme in folate metabolism, plays an important role in DNA methylation. It has been suggested that abnormal DNA methylation contributes to the pathogenesis of schizophrenia and congenital anomalies. The previous findings regarding the genetic relationship between MTHFR and schizophrenia are controversial. This study investigated the assoc...

متن کامل

Study of Minor Physical Anomalies in Complete Nuclear Mexican Families. Evidence of Neurodevelopmental Problems in Schizophrenia

INTRODUCTION Minor physical anomalies (MPA) are dysmorphic features that reflect deviations in early development, are morphological variants that appear during the first trimester of pregnancy and could be used as a marker of disease risk in susceptible people. The literature agrees that the number of MPA is higher in patients with schizophrenia compared with their relatives and healthy subject...

متن کامل

A clinical study of minor physical anomalies in patients with schizophrenia

Background: Minor physical anomalies (MPA) are unusual morphological deviations that have no serious medical or cosmetic significance to an individual. But however minor they may be, various studies across the world have revealed their significance as a possible endophenotype of schizophrenia. This study is an attempt towards understanding the various sociodemographic and illness correlates as ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Schizophrenia bulletin

دوره 30 2  شماره 

صفحات  -

تاریخ انتشار 2004